Single cell analysis of the inner ear sensory organs
نویسندگان
چکیده
منابع مشابه
Single cell analysis of the inner ear sensory organs
The inner ear is composed of a complex mixture of cells, which together allow organisms to hear and maintain balance. The cells in the inner ear, which undergo an extraordinary process of development, have only recently begun to be studied on an individual level. As it has recently become clear that individual cells, previously considered to be of uniform character, may differ dramatically from...
متن کاملSingle-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear
In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. Each individual sensory epithelium is composed of highly heterogeneous populations of cells based on physiological and anatomical criteria. However, limited numbers of each cell type have impeded transcriptional characterization. Here we generate...
متن کاملDevelopment of the mouse inner ear and origin of its sensory organs.
The molecular mechanisms dictating the morphogenesis and differentiation of the mammalian inner ear are largely unknown. To better elucidate the normal development of this organ, two approaches were taken. First, the membranous labyrinths of mouse inner ears ranging from 10.25 to 17 d postcoitum (dpc) were filled with paint to reveal their gross development. Particular attention was focused on ...
متن کاملThe Candidate Splicing Factor Sfswap Regulates Growth and Patterning of Inner Ear Sensory Organs
The Notch signaling pathway is thought to regulate multiple stages of inner ear development. Mutations in the Notch signaling pathway cause disruptions in the number and arrangement of hair cells and supporting cells in sensory regions of the ear. In this study we identify an insertional mutation in the mouse Sfswap gene, a putative splicing factor, that results in mice with vestibular and coch...
متن کاملSENATE HOUSE VIALET STREET ONDONW C1E7HU Wound Repair in Sensory Organs of the Avian Inner Ear
Hair cells are the sensory receptors of the inner ear, converting sound and accelerations into neuronal signals. Unlike mammals, birds are able to regenerate their sensory function after auditory or vestibular trauma. Sensory regeneration requires a composite programme of epithelial repair, hair cell production and functional reinnervation. The purpose of this thesis was to explore the mechanis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2017
ISSN: 0214-6282
DOI: 10.1387/ijdb.160453ka